Failure of rifampicin and co-trimoxazole in Q fever endocarditis.

Preparation and Evaluation of Rifampicin and Co-trimoxazole-loaded Nanocarrier against Brucella melitensis Infection

Background: Brucellosis or Malta fever is a contagious infection common between human and domestic animals. Many antibiotics are used for brucellosis treatment, but they are not efficient and put heavy burden on society. Co-trimoxazole and rifampicin are two candidates for brucellosis treatment. In this study, we aimed to enhance the efficacy of these antibiotics using designed nanoparticles. M...

Chronic Q fever endocarditis.

Eight patients with chronic Q fever endocarditis were treated with tetracycline for up to 40 months. In addition, five of these patients received co-trimoxazole. Six patients had prosthetic valves. Two patients who had Q fever endocarditis on their native valves required valve replacement because of haemodynamic difficulties: in only one did the Q fever endocarditis contribute to the haemodynam...

Chronic Q fever endocarditis.

Q fever tricuspid valve endocarditis.

Q fever is a zoonosis caused by Coxiella burnetii. The most frequent clinical expression of the chronic form is a bacterial culture negative aortic or mitral endocarditis. A case of tricuspid valve endocarditis due to C burnetii is described, with a favourable outcome after treatment with doxycycline and hydroxychloroquine.

Pseudomonas cepacia endocarditis treated with co-trimoxazole and kanamycin.

An outbreak of infection by Pseudomonas cepacia, previously reported (Speller, Stephens, and Viant, 197i), arising from contaminated aqueous chlorhexidine solutions, included two cases of endocarditis affecting recently-inserted prosthetic mitral valves. The bacterium was resistant to most chemotherapeutic agents, but treatment with a combination of co-trimoxazole (trimethoprim plus sulphametho...